The causes of polycystic kidney: theories and hypotheses

  • The causes of polycystic kidney: theories and hypotheses

    This disease is known for a long time. What theories have not been put forward to somehow explain the causes of polycystic kidney disease. Some considered polycystosis to be some kind of new education. Others were of the opinion that the disease has a syphilitic origin, as one of the consequences. As early as the 19th century, a certain R.Virchov substantiated his version, having come to the conclusion that this inflammatory-retentive process.

    Later, most doctors came to the conclusion that violations occur even when the kidneys are in an embryonic state, that is, there is no complete fusion of the secretory and secretory apparatus. As a result, there is no contact of the growing ureter with the metanephrogenic tissue. Cyst formation occurs, since tubules are not connected to the urinary system.

    The causes of polycystic kidney: modern theories

    Studies in recent years show that it's all about nephrons. More precisely in their education. As is known, at the embryonic stage of development the ampoule should be divided into two parts, one of which forms a new nephron, the other is connected with the already formed one. Further there is a further process of division and everything is repeated.

    The causes of polycystic kidney, according to scientists, is that the patients do not, and cysts begin to form. At the same time, their sizes can be from completely microscopic to very large ones. However, not all nephrons die. Some of them continue to develop in these cyst formations. Although in an altered state, they continue to function. That is why it is important not to remove small cysts, having a diameter of 1-1.5 centimeters, during operations.

    Immune hypothesis

    A number of authors were interested in this behavior of nephrons in cysts. The research was continued. Histology showed that if the cysts are located on the entire surface of the kidney, then along with the altered, quite normal tubules and glomeruli work. So the whole point is the immunological incompatibility associated with the ureter and metanephrogenic blastoma.

    The case - in the genetics of

    Later it became clear that polycystic kidney disease is nothing more than a genetically hereditary disease, and it can be transmitted from either one or both parents.

    This is important! Statistics show that autosomal dominant polycystosis develops in 90 percent of patients and is transmitted from one of the parents. At the same time in childhood, the disease rarely shows itself. And only by 30-40 years can begin unpleasant consequences and require treatment.

    But autosomal recessive polycystosis is usually found much less often and is transmitted from both the father and mother. The consequences of this usually lead to the fact that the newborn child not only gets sick early, but the lethal outcome, unfortunately, happens quite often.

    Interesting is the fact that polycystic kidney disease does not necessarily have to pass from generation to generation. It happens that a person suddenly has a certain mutation, which leads to the onset of this disease.

    Factors influencing the occurrence of polycystosis

    This bilateral anomaly can develop very differently on different kidneys. It happens that it is closely related to other diseases, such as: polycystic liver or pancreatic cancer. But the main factor nevertheless consider pyelonephritis. At the same time, for a long time he can not give himself away. The disease proceeds imperceptibly. But if it is not treated, then a sharp deterioration in health can occur. Violated urination, there is venous stasis, the number of non-working nephrons increases.

    And along with the kidneys, the liver suffers. Protein, carbohydrate, antitoxic, fatty, steroid and other processes occur with impairments. And, if in the process of treatment they can be minimized, then this is considered a good sign, saying that it is possible to carry out the operation in the future.

    Kidney polycystic disease - not yet a sentence

    This disease can strike both an adult and a child. At one time it was believed that the development of polycysticosis proceeds in exactly the same way. But recent research has shown that this is not the case.

    In children, and in pathogenetic and clinical terms, a slightly different picture is observed. Not to mention the fact that adult patients it is an order of magnitude higher. So much will depend not only on the lifestyle, but also on the timely diagnosis and on the time of treatment. It is impossible to tolerate the development of ailment into a chronic stage.

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