What are the causes, symptoms, treatment of hyperbilirubinemia?
Hyperbilirubinemia is a disease characterized by an increase in serum bilirubin. Bilirubin is one of the bile pigments, which has a yellowish-red color. This substance is synthesized from the hemoglobin of erythrocytes, which decay as a result of the involuntary changes in the reticuloendothelial system, that is, in the cells of the spleen, bone marrow, liver, and also in the connective tissues of the organs( histiocytes).
Causes of hyperbilirubinemia
There are many reasons for increasing bilirubin content, from excessive formation of it( massive simultaneous destruction of a large number of red blood cells) and ending with impaired excretion of the substance from the body or the process of capture from blood plasma and metabolism in liver cells. Distinguish between direct and indirect bilirubin and depending on what stage of metabolism is the process of transformation - these concepts show whether this substance is in close connection with the proteins of serum for transportation, or whether the compound has already completed the metabolism in the liver cells.
Increased indirect bilirubin is called unconjugated hyperbilirubinemia. This disease is associated with increased hemolysis, and the name it received as a result of the fact that bilirubin enters the liver in an unrelated form. An increase in the level of unconjugated bilirubin is observed in the presence of hemolytic disease of the fetus or newborn, as well as in hereditary and acquired hemolytic anemia. Also, the manifestation of unconjugated hyperbilirubinemia is facilitated by poisons poisoning and mechanical damage to erythrocytes, as well as by certain liver diseases.
The increase in the content of direct, conjugated, bilirubin was called "conjugation hyperbilirubinemia".The main cause of the development are violations during the removal of bilirubin from the body. It is present for various forms of hepatitis, cirrhosis of the liver and for obstructions to the outflow of bile( stones in the gallbladder, etc.).Also, the prolonged intake of hormonal contraceptives or the use of steroids( prescribed for the treatment of diseases of the body, as well as for bodybuilding athletes) also contributes to the increase of direct bilirubin.
Symptoms of the disease
With a high content of bilirubin in the blood, there is a threat of violations from the central nervous system, namely, the person becomes inhibited, sluggish, easily overworked. A complication is also possible, when bilirubin enters the nuclei of the brain stem and has a toxic effect on them. This is especially true for newborns. The Krigler-Nayyar syndrome( congenital malignant hyperbilirubinemia of unconjugated nature, which is inherited), usually leads to the death of sick children.
With a mild illness, general weakness and fatigue are observed. In such cases, the liver is not enlarged in size and painless, the treatment will bring an effect and the work capacity will remain.
Benign hyperbilirubinemia, as a rule, is congenital as a result of a congenital abnormality in the functioning of the liver, which does not have a serious effect on the body as a whole. A characteristic sign of the disease is yellow( icteric) coloration of the skin and eye proteins, especially expressed as a result of overwork, stress. Sometimes when exacerbation there is pain in the right hypochondrium, general weakness, nausea and anorexia.
Treatment and therapy methods
If benign hyperbilirubinemia is identified as a result of the study, treatment is included in the diet. During remission and if you do not have concomitant disorders in the work of the gastrointestinal tract, diet No. 15 is prescribed;at the time of exacerbations, as well as in the presence of diseases of the gallbladder, doctors recommend using diet number 5( prescribed for most acute and chronic liver diseases).
Special hepatic therapy for this form of the disease is not needed. As a rule, patients are prescribed a course of vitamin therapy and cholagogue preparations. In case of violations in the synthesis or excretion of bilirubin, thermal and electrical procedures in the liver region are contraindicated. It is necessary to limit physical and nervous stresses in order to avoid the acute form of the disease.
Hyperbilirubinemia in newborns is treated primarily with phototherapy, which uses fluorescent light from the ultraviolet spectrum to transform bilirubin and accelerate its excretion from the baby's body. Standard phototherapy is used in hospitals. But newborns who suffer from yellowing with no other signs of malaise, can be prescribed treatment at home using an optical fiber coverlet. Such a cover is slower than a fluorescent lamp, reduces the bilirubin content, so it is only applicable in mild forms of the disease.
Fluorescent light, which is used for phototherapy, is not dangerous with the proper organization of treatment. For children during the procedure, a bandage is worn over the eyes so as not to damage the organs of vision( to prevent a burn of the mesh shell of the eyes).The dressing is removed during the baby's feeding time. As a rule, the procedure of light irradiation is carried out with short intervals of 2-4 hours before the time when bilirubin will return to normal. Children are not disturbed by dark bandages before their eyes, since before birth, in the womb, they were in total darkness and this is their usual situation.
Syndrome of hyperbilirubinemia is a congenital form of the disease, so its treatment is to maintain the body and ensure normal life. In congenital forms, there are exacerbations during which it is necessary to undergo a course of treatment with the Sorbovit-K sorbent, and after lowering the bilirubin content, it is necessary to return to preventive measures, that is, to take vitamins, choleretic preparations and diet.