Cytomegalovirus treatment with folk remedies

CMV infection is a viral disease predominantly in young children, characterized by a variety of clinical symptoms and a specific morphological pattern with the presence of cytomegal cells on the background of lymphohistiocytic infiltrates. The causative agent belongs to the Herpesviridae family( human herpesvirus type 5).Features of CMV: a large DNA genome( nucleocapsid diameter 100-120 nm), the possibility of replication without cell damage, slow replication, relatively low virulence, a sharp inhibition of cellular immunity. Like other viruses of this family, CMV is able to cause persistent and latent infection and reactivate in conditions of weakened immunity. CMV is prevalent everywhere. From 0.5% to 2.5% of newborns are infected with it during the period of intrauterine development.

The nature of the affected fetus depends on the timing of infection with CMV.Infection in early pregnancy leads in part to intrauterine death of the fetus and miscarriages, stillbirths, the birth of children with malformations( eg, narrowing of the pulmonary trunk and aorta, defects of the interatrial and interventricular septa, fibroelastosis of the myocardium, microcephaly, lung hypoplasia, atresia of the esophagus, anomaliesstructure of the kidneys, etc.).When infecting in late pregnancy, developmental anomalies are not formed. However, from the first days after birth, the child is exposed to jaundice, hepatosplenomegaly and hemorrhagic syndrome. Other organs and systems are also affected: pulmonary( interstitial pneumonia), central nervous system( hydrocephalus, meningoencephalitis), gastrointestinal tract( enteritis, colitis, pancreatic polycystosis), kidneys( nephritis).

With intrapartum and early postnatal infection, clinical signs of the disease are detected in the first 1-2 months after birth.

CMV affects many types of blood cells and can persist in monocytes, macrophages, megakaryocytes, which in some cases leads to thrombocytopenia.

Laboratory diagnosis of CMV infection is based on the detection of specific ATs in the blood serum of infected or DNA virus in body fluids( eg blood, saliva, urine, ejaculate, punctate liver, lymphatic catch) by PCR, as well as Ag virus in peripheral lymphocytesblood by indirect im-munofluorescence( fast and sensitive method).

Detection of virus particles in the blood of a patient using PCR is used to diagnose CMV infection and control the effectiveness of antiviral treatment. Unlike serological methods of diagnosis of CMV infection, in which AT is detected to CMV, PCR allows to detect the presence of CMV directly and quantitatively express its concentration in serum. The detection of CMV is of great importance in the diagnosis of perinatal pathology. Intrauterine and perinatal transmission of CMV can have serious consequences. CMV infection during pregnancy often occurs in subclinical form and is accompanied by relatively unexpressed symptoms. PCR in such cases allows to reveal the etiologic factor of the disease. The material for the study can serve as urine sediment cells( newborns), epithelium of the cervical canal of sick women, amniotic fluid, scrapings from the conjunctiva of the eye and urogenital tract, saliva, punctate liver.

Antibodies to cytomegalovirus class IgM and IgG in serum

AT IgM to CMV in serum are not normally present.

In serological diagnosis of CMV infection, many reactions are used, but those that can detect AT, classified as IgM and IgG classes, are truly useful. Recently, the most widely used method ELISA.

AT to CMV class IgM appear within 1-2 weeks after the onset of the disease and indicate a fresh infection or reactivation of a latent and persistent infection. However, it should be borne in mind that in some patients an increase in the content of AT-class IgM may not occur within the first 4 weeks after the onset of the disease. Elevated levels of AT-class IgM to CMV can persist for 12 months in 24% of patients. The presence of ATM IgM in pregnant women is an indication for cordocentesis and fetal blood test for the presence of an Ig-class AT.In the presence of AT IgM, the fetus is considered infected. With congenital CMV infection, the titre of Ig IgM is high, it gradually decreases, in the 2nd year of the child's life they may be absent. When evaluating the results of detecting Ig IgM it should be taken into account that the presence of rheumatoid factor can lead to false positive results of the study.

AT to CMV of IgG class appear in 2-4 weeks after infection, in patients who have recovered they remain up to 10 years. The presence of infection is indicated only by a 4-fold or more increase in the titer of AT IgG in the study of paired sera. The frequency of detecting IgG class AT can reach 100% among different population groups.

The group with the greatest risk for CMV infection is people with artificial or natural immunosuppression: HIV-infected, recipients of organs, tissues, cells, cancer patients.

Detection of IgM and IgG antibodies to CMV is used to diagnose the acute period of CMV infection, including in immunodeficient conditions, HIV infection, lymphoproliferative diseases and the determination of the period of convalescence of CMV infection.