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Antibodies to streptococcus A, B, C, D, F, G in serum

  • Antibodies to streptococcus A, B, C, D, F, G in serum

    The titer of AT to streptococcus is normal in serum of 12-166 ED.

    AT to group-specific polysaccharide( anti-A-CHO) polysaccharide appears in the first week of infection, their titer rapidly increases, reaching a peak at week 3-4 of the disease. The increase in the titre of AT at 10-14 days is considered to be diagnostic by no less than 4 times when examining paired sera. It should be borne in mind that even active streptococcal infection causes an increase in AT titer by 4 times in only 70-80% of patients. The AT test for group A streptococcal polysaccharide is usually used as a supplement to the detection of ASO and AT to deoxyribonuclease B in patients with rheumatic fever. There is a highly specific correlation between the constant content of anti-A-CHO in the blood serum and the activity of rheumatic carditis. With effective treatment, the anti-A-CHO content decreases several months after the other markers of streptococcal infection.

    for diagnosis of streptococcal infection by streptococci other groups using the ELISA method to detect specific antibodies to bacterial wall carbohydrates, mainly groups C and G. However, these studies have not been widespread. Changing

    titer antibodies to streptococci with different diseases presented in Table. .

    Table titer antibodies to Streptococcus in various diseases [Wallach JMD, 1996]

    Table titer antibodies to Streptococcus in various diseases [Wallach JMD, 1996]

    Diseases

    Titer ATED

    Active rheumatic fever

    500-5000

    Inactive rheumatic fever

    12-250

    Rheumatoid arthritis

    12-250

    Acute glomerulonephritis

    500-5000

    Streptococcal infection of the upper respiratory

    100-333

    pathways

    Collagenoses

    12-250

    The definition of AT for streptococci is used to diagnose streptococcal infection in the following diseases:

    ■ catarrhal, lacunar, follicular angina;

    ■ erysipelas, scarlet fever, glomerulonephritis, rheumatism;

    ■ septic conditions;

    ■ chronic inflammatory diseases of the lungs.