Antibodies to streptococcus A, B, C, D, F, G in serum

The titer of AT to streptococcus is normal in serum of 12-166 ED.

AT to group-specific polysaccharide( anti-A-CHO) polysaccharide appears in the first week of infection, their titer rapidly increases, reaching a peak at week 3-4 of the disease. The increase in the titre of AT at 10-14 days is considered to be diagnostic by no less than 4 times when examining paired sera. It should be borne in mind that even active streptococcal infection causes an increase in AT titer by 4 times in only 70-80% of patients. The AT test for group A streptococcal polysaccharide is usually used as a supplement to the detection of ASO and AT to deoxyribonuclease B in patients with rheumatic fever. There is a highly specific correlation between the constant content of anti-A-CHO in the blood serum and the activity of rheumatic carditis. With effective treatment, the anti-A-CHO content decreases several months after the other markers of streptococcal infection.

for diagnosis of streptococcal infection by streptococci other groups using the ELISA method to detect specific antibodies to bacterial wall carbohydrates, mainly groups C and G. However, these studies have not been widespread. Changing

titer antibodies to streptococci with different diseases presented in Table. .

Table titer antibodies to Streptococcus in various diseases [Wallach JMD, 1996]

Table titer antibodies to Streptococcus in various diseases [Wallach JMD, 1996]

Diseases	Titer ATED
Active rheumatic fever	500-5000
Inactive rheumatic fever	12-250
Rheumatoid arthritis	12-250
Acute glomerulonephritis	500-5000
Streptococcal infection of the upper respiratory	100-333
pathways
Collagenoses	12-250

The definition of AT for streptococci is used to diagnose streptococcal infection in the following diseases:

■ catarrhal, lacunar, follicular angina;

■ erysipelas, scarlet fever, glomerulonephritis, rheumatism;

■ septic conditions;

■ chronic inflammatory diseases of the lungs.