The reaction of inhibition of migration of leukocytes in the blood
The values of the inhibition of migration of leukocytes in the blood are normal: migration with phytohemagglutinin( PHA) is 20-80%, with concanavalin A( ConA) 40-75%, with specific Ag 80-120%.
The inhibition of migration of leukocytes allows one to assess the ability of T-lymphocytes to produce lymphokines in response to antigenic stimulation. This test evaluating the functional activity of T-lymphocytes can be used to diagnose immunological failure( reaction with mitogens), hypersensitivity( allergies) of delayed type( reaction with a specific Ar or allergen).The inhibition of migration of leukocytes can also be used to detect an immune response to infectious agents, to determine the degree of histocompatibility and in tumor processes.
This test characterizes the activity of the inflammatory process. An increase in the inhibition of migration of leukocytes should be considered as a prognostically favorable factor;clinically it is accompanied by faster recovery of patients with acute surgical diseases after surgical intervention and shortening of the postoperative period. The inhibition of migration of leukocytes can be very significant in allergic reactions. Diseases and conditions leading to a change in the inhibition of migration of leukocytes are presented in Table. .
Table Diseases and conditions that lead to a change of the inhibition of migration of leukocytes
Table Diseases and conditions leading to a change in the inhibition of migration of leukocytes
| Increase in the indicator |
Decrease in the index |
| Functional deficiency of T-lymphocytes, immunodeficiency( including HIV infection), congenital defects of the T-link of immunity Chronic inflammationss Neoplasm Severe burns, injuries, stress Intestinal and renal protein loss, aging Insufficiency of nutrition Treatment with cytostatics and immunosuppressants Ionizing radiation |
Reduction of migration with a specific Ar or allergen testifies to lymphocyte sensitization to these Ag( allergies) Reduction of migration with mitogenstestifies to the hyperactivity of the immune system in allergic and autoimmune diseases |