The total number of lymphocytes( CD20) in the blood
The total number of CD20-lymphocytes in the blood for adults is normally 8-19%, absolute values - 0.19-0.38x109 / l.
CD20-lymphocytes are cells of humoral immunity, responsible for the synthesis of AT.They are formed in the bone marrow from stem cells, where the first steps of differentiation are going on about
.According to modern ideas, the development of B-lymphocytes passes from the stem cell stage to the early and late predecessors and, finally, to the mature cell. B-lymphocytes are mainly concentrated in the peripheral lim-phoid organs. Peripheral blood contains only 15-20% of their total number. The ratio of populations in the total B-lymphocyte pool is important in assessing humoral immunity: B-lymphocytes with IgM-receptors are 3-10%;with IgG-receptors - 2-6%, with IgA-receptors - 1-3%.With the violation of the ratio of B-lymphocytes, many diseases are associated. Insufficiency of B-cells leads to severe immunodeficiency, and their excessive activity - to the development of autoimmune pathology.
It should be noted that the number of B-lymphocytes in the peripheral blood, a fairly stable indicator of homeostasis, varies little with different effects, so deviating its value from normal may serve as one of the important criteria for immunopathology.
In the second half of a normally developing inflammatory process, in most cases the relative amount of B-lymphocytes in the blood rises( especially in viral infections).As a rule, this indicator increases in parallel with the increase in regional lymph nodes. The relative content of B-lymphocytes usually increases with prolonged inflammatory processes. For the clinician, the most important is the analysis of the level of B lymphocytes after the end of the clinical manifestations of the inflammatory process. In all cases, the normalization of the relative amount of B-lymphocytes indicates a complete end of the process. Diseases and conditions in which the amount of CD20-lymphocytes in the blood vary varies as follows.
Table Diseases and conditions in which the amount of CD20 lymphocytes in the blood changes
Increase in the
Index Acute bacterial, fungal and parasitic infections HIV infection( initial period) Chronic liver disease, liver cirrhosis, viral hepatitis Autoimmune diseases Rheumatoid arthritis SLE
Rheumatism, collagenosis Sarcoidosis, cystic fibrosis Waldenström's disease Chronic infectious mononucleosis(at the age of 3-5 months) Congenital hypogammaglobulinemia or agammaglobulinemia Neoplasms of the immune system Treatment of cytostatics and immuno-depressants
Condition after removal of the spleenInsufficiency of humoral immunity