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Antibodies to HBEAg( anti-HBe) in serum

  • Antibodies to HBEAg( anti-HBe) in serum

    Anti-HBe in serum is normal.

    The appearance of anti-HBe, AT usually indicates an intensive elimination of HBV virus from the body and a minor infection of the patient. These ATs appear in the acute period and persist up to 5 years after the infection. In chronic persistent hepatitis, anti-HBe is detected in the patient's blood together with HBsAg. Seroconversion, that is, the transition of HBeAg to anti-HBe, with chronic active hepatitis, is more often prognostically favorable, but the same seroconversion with pronounced cirrhotic transformation of the prognosis does not improve.

    The blood test for the presence of anti-HBe is used for the following purposes:

    ■ HBV diagnosis:

    □ initial stage of the disease;


    Weeks after infection

    Fig. Dynamics of markers of viral hepatitis B in the first weeks after infection

    Weeks after infection

    Fig. Dynamics of hepatitis B markers in the first weeks after infection

    Prodromal acute Acute convalescence

    phase infection

    Prodromal acute Acute convalescence

    phase infection


    Months after infection

    Fig. Dynamics of blood markers in acute viral hepatitis In

    Months after infection with

    Fig. Dynamics of blood markers in acute viral hepatitis In

    Months after infection

    Years after infection

    Fig. Dynamics of blood markers in chronic viral hepatitis In

    □ acute infection;

    □ early stage of convalescence;

    □ reconvalescence;

    □ late stage of convalescence;

    ■ diagnosis of HBV in the near past;

    ■ Diagnosis of chronic persistent HBV.

    Detailed dynamics of the main HBV markers in the first weeks after infection is shown in Fig.and in Fig.and 8-8 are the changes in the level of blood markers in acute and chronic HBV infection over a longer period of time.

    Criteria for the Presence of Chronic HBV:

    ■ Detection of HBsAg in the blood for more than 6 months;

    ■ continuous or periodic detection of HBV DNA in the blood;

    ■ continuous or periodic increase in ALT / AST activity in the blood;

    ■ Morphological signs of chronic hepatitis in the histological study of liver biopsy.