Gouty kidney: causes of pathology
The gouty kidney is a general term that unites the various lesions of this organ with the simultaneous development of gout. At the heart of the manifested changes in the kidneys is the impaired disparity in the increase in the production of uric acid and the deterioration of its ability to excrete from the body. This situation occurs with the development of primary gout - when there is a primary increase in the processes of synthesis of uric acid due to a violation of metabolism and a deficiency in the concentration of a particular enzyme.
How the gouty kidney
is manifested In general, with the development of the gouty kidney, a slowly progressing interstitial process and the formation of stones are observed. Often there is kidney blockage by means of uric acid or due to serious damage to the renal tubules, which is responsible for kidney failure. In this case, the symptoms of secondary infectious damage of the kidneys, complications in the form of increased pressure, etc. are revealed.
A mild manifestation of the urinary syndrome can for a long time remain the only sign of a gouty kidney until symptoms of kidney failure form simultaneously with hypertensive disease and azotemia. Not always kidney pathology is accompanied by classical signs of gout - arthritis, the presence of tofus in the joint zone and in the auricles.
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Another characteristic of gout complication is the formation of kidney stones - 10 - 20% of patients with gout suffer from urolithiasis pathology. And the plugging of the urinary canals creates favorable conditions for urine stagnation and the attachment of the inflammatory process.
Another variant of gouty kidney damage is a urinary blockade of the organ that develops with the active development of increasing the concentration of uric acid in the blood, which contributes to the formation of urinary stones, causing obstruction and acute kidney failure. Sometimes renal colic and gouty arthritis are attached to the pathological process. A pronounced increase in the concentration of uric acid occurs with extensive decay of nucleoproteins in patients with leukemia in the management of large amounts of cytostatics.
Kidney damage can develop long before the formation of gouty arteritis or tofus. Control of the concentration of uric acid in the blood is considered the main test of diagnosis.
Recently, the results of treatment of patients with gout damage, including kidneys, are improving markedly. The positive perspective and prognosis of pathology, as well as the preservation of the functional abilities of the kidneys are tracked. In modern medicine, treatment can end in success, provided it is accurately carried out. Treatment involves the organization of dietary, pharmacological therapy, conducted in between acute gouty attacks. In the presence of restrictions on the state of health, the patient is prescribed course therapy with the following medicines:
- Diuretics that help to prevent reabsorption of the already isolated and filtered uric acid in the kidneys.
- Urostatics that help delay the production of uric acid.
If used in the treatment of diuretics it is required to consume a large amount of liquid - at least two liters per day in the daytime and even at night to prevent the deposition of uric acid in the urinary canals.
The main role in the treatment is given to medicines that slow down the production of uric acid. For example, allopurinol was initially successfully used for the treatment of neoplastic tumors, and later it was actively used to treat gout. Reception of this tool allows to achieve a noticeable reduction of urate stones and may contribute to their complete elimination. This drug is well tolerated by the human body, but occasionally there may be allergic reactions.
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Sometimes the healing process drags on for years. And throughout the treatment will need to constantly adjust the dose of drugs, the beginning of the course of treatment, taking into account the progression of uricemia.
Nutrition for gouty kidneys implies a complete refusal to consume foods with a high concentration of purine - offal, beer, meat, some fish. It is better to eat dark meat, fish in moderate doses, chicken breasts, egg and milk protein. It is also recommended to limit the use of refined sugar, since the human body with gout is susceptible to the onset of diabetes mellitus.
Prevention of gout development will be quite successful if all the recommendations of the attending physician are observed. Proper nutrition is necessary for people. Being in a group at risk of disease damage - while the calorie content of food should be reduced. Also, periodic monitoring of the concentration of uric acid in the blood throughout life. Such procedures allow to restore the wrong metabolism and normalize the work of the patient's body.Like the article? Share with friends and acquaintances: