Symptoms of autoimmune hepatitis - diagnosis and treatment of the disease

Autoimmune hepatitis is a chronic inflammatory process in the liver of an unknown nature that is characterized by periportal or more extensive inflammation, as well as the presence of hypergammaglobulinemia and tissue autoantibodies.

Autoimmune hepatitis in children is mainly found at the age of 10 years and older. Three quarters of the total number of cases is made up of women over the age of 40.

Chronic autoimmune hepatitis can remain asymptomatic for months or years until the jaundice is revealed and an accurate diagnosis can be made. Recognize the disease can be and earlier, if you conduct a study for the presence of stigma of the liver disease or the results of a biochemical study of liver function will differ from the norm.

The onset of the disease can be of a different nature. Two variants of the onset of this disease can be distinguished:

1. In some patients, the disease begins, like acute viral hepatitis: weakness, lack of appetite, urine darkens, jaundice with severe hyperbilirubinemia, and high levels of aminotransferases in the blood.
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2. The second variant of the onset of autoimmune hepatitis is characterized by the predominance of extrahepatic manifestations and an increase in temperature, which leads to an incorrect diagnosis of systemic lupus erythematosus, sepsis, rheumatism or rheumatoid arthritis.

The cause of autoimmune hepatitis is still unknown. Due to immune changes, the level of y-globulin in the serum is extremely high. Approximately 15% of patients have positive results of LE-cell test and the appearance of the term "lupoid hepatitis".A large number of patients found tissue antibodies.

Symptoms and symptoms of autoimmune hepatitis

Autoimmune hepatitis is characterized by the following symptoms:

1. Severe general weakness, fatigue, decreased ability to work, worse appetite, pain and heaviness in the right upper quadrant, nausea, jaundice, pruritus, and joint pain, increasedbody temperature, the appearance of skin rashes and menstrual cycle disorders.
2. When examined, jaundice of varying severity is manifested, hemorrhagic exanthems on the skin in the form of dots or spots.
3. In severe cases of disease on the body appear vascular sprouts and palmar hyperemia.
4. Often, the digestive tract system is affected.
5. Hepatomegaly is the most characteristic sign of autoimmune hepatitis. The liver is painful, and its consistency is moderately dense. It is also possible to increase the spleen, in some patients there is a transient ascites . Almost all patients have chronic gastritis with a decreased secretory function. Extrahepatic systemic manifestations.

Autoimmune hepatitis is a systemic disease in which many organs and systems are affected. Patients may have pleurisy, myocarditis, pericarditis, ulcerative colitis, glomerulonephritis, autoimmune thyroiditis, iridocyclitis, Cushing's syndrome, diabetes mellitus, hemolytic anemia.

Autoimmune Hepatitis - Symptoms in severe cases can manifest as hyperthermia. In this case, acute recurrent polyarthritis with involvement of large joints without their deformation is observed.

One of the most important extrahepatic systemic manifestations is glomerulonephritis, which most often develops in the terminal stage. A kidney biopsy often reveals mild glomerulitis.

It is known from the histories of autoimmune hepatitis that extrahepatic manifestations of the disease do not dominate the clinical picture and develop much later. However, with systemic lupus erythematosus, which is often confused with autoimmune hepatitis, extrahepatic symptoms in the clinical picture dominate, developing much earlier than the symptoms of autoimmune hepatitis.

Diagnosis of

In the diagnosis of autoimmune hepatitis, it is important to determine the following markers:

• antinuclear antibodies( ANA);
• antibodies to liver and kidney microsomes( anti-LKM);
• SMA antibodies to smooth muscle cells, soluble hepatic( SLA), and hepatic pancreatic( LP) antigens;
• is an asialoglycoprotein for receptors( hepatic lectin) and antigens of the plasma membrane of hepatocytes( LM).

Treatment of autoimmune hepatitis

Most often as a pathogenetic therapy, glucocorticosteroids are used that reduce the activity of the pathological process in the liver. This is due to immunosuppressive effect on K-cells, a decrease in the intensity of autoimmune reactions, an increase in the activity of T-suppressors directed against hepatocytes.

The main drugs are prednisolone or methylprednisolone. The initial daily dose of prednisolone is 60 mg during the 1 week, 40 mg in the 2nd week, at the 3rd and 4th weeks, 30 mg, and the maintenance dose is 20 mg. To reduce the daily dose of the drug should be slow( by 2.5 mg every 1-2 weeks), to the supportive, which is taken before complete clinical and laboratory and histological remission. Treatment is carried out for a long time: from 6 months to 2 years, and in some patients - throughout life.

Autoimmune hepatitis - the forecast is mostly favorable. Everything depends on the stage of the disease and the measures taken in time. Indications for liver transplantation are relevant in cases when it has not been possible to achieve remission with the help of corticosteroids, or at a far-reaching process, when cirrhosis is already developing. Survival after transplantation is comparable to those in whom remission was achieved with corticosteroids. Repeated liver biopsy after transplantation does not reveal a recurrence of autoimmune chronic hepatitis.