Diseases in which aspartate aminotransferase is increased

Aspartate aminotransferase( ACT) is an endogenous, intracellular enzyme belonging to the transaminase class, and is also found in large numbers in the cellular structures of many organs - the kidneys, the skeletal musculature, the tissue fibers of the human nervous system, the hepatic tissue, and also less in thepulmonary, splenic tissues, and pancreatic tissue. ATS takes part in the transfer and is a catalyst for metabolic processes of amino acids, stimulating their cleavage, and also refers to nonspecific diagnostic markers. It is tied that a change in the level toward increasing or decreasing their number, indicates the presence of diseases or the development of pathological processes.

Why do I need to know the AST rule?

In the case of even a slight damage to the integrity of internal tissues or the development of pathological processes that lead to cell cytolysis, AST enters the bloodstream, resulting in an increase in the amount of endogenous enzyme in the blood.

In order to know the level of aspartate aminotransferase in the blood, special laboratory, biochemical blood tests are carried out in medical centers, the results of which allow to determine the general state of a person, assess the liver, pancreas, spleen, diagnose diseases of the cardiovascular system or pathology of muscle tissue.

Norms of

The norm of aspartate aminotransferase in the bloodstream in men should be within 41 U / liter, the norm for women is 31 to 36 U / liter, for children from one year to 18 years - from 15 to 60 U / L, for newbornsthe concentration of AST in the blood should be 25-75 U / l.

The synthesis of ACT passes inside cells, and normally only a small amount can penetrate into the lymph or the bloodstream. In pregnancy, the AST concentration should not exceed 31 U / l.

Increase in AST concentration in blood

Aspartate aminotransferase concentration in blood serum, as already noted above, is observed as a result of tissue damage of those organs in which the enzyme is contained in a larger amount.

Aspartate aminotransferase, unlike alanine aminotransferase( ALT), is found not only in the cytosol but also in the mitochondria of hepatocytes, the determination of the concentration in the bloodstream of the AST is a significant diagnostic factor by which the liver status can be determined. Also, a large number of ACT is contained in the heart cells, therefore, in any diseases or disorders in the work of the cardiovascular system, an increase in the concentration of aspartate aminotransferase in the blood is observed.

Aspartate aminotransferase elevation is diagnosed with:

1. Myocardial infarction, with the maximum level of serum AST occurring after 22-24 hours, and only after 5-6 days returns to normal;
2. Severe form of coronary insufficiency, in which the maximum activity of AST is diagnosed after 23-24 hours from the development of the disease;
3. In acute or chronic hepatitis, cirrhosis, necrosis of liver tissue, as well as in case of the appearance of malignant neoplasms( cancer disease) or their metastases, fatty degeneration of the body, fatty degeneration of liver cells during pregnancy;
4. With necrosis or damage to the cellular structures of the muscular or skeletal tissues, dermatomyositis, progressive muscular dystrophy, after suffering extensive injuries, burns, heat stroke. With rhabdomyolysis, the AST concentration can be increased by 20 or more times;
5. Alcohol intoxication;
6. Disorders of secretory function of the gallbladder;
7. Thromboembolism of the pulmonary artery;
8. Obtuse jaundice;
9. Infectious mononucleosis;
10. Local radiation sickness;
11. Poisoning by chemical substances( tetrochloromethane, chlorophos) or poisonous fungi;
12. Acute pancreatitis, cholecystitis;
13. Viral lesions of the lymphatic system;
14. After heart surgery. Acute form of rheumacarditis, pancarditis, myocarditis.

Causes that promote aspartate aminotransferase in the blood can also be associated with increased muscle load, prolonged physical exertion, with the use of alcoholic beverages. A slight increase in AST in the blood can also be caused by the intake or administration of certain medications, for example, valerian, echinacea, antibiotics, barbiturates, any hepatotoxic drugs.

Aspartate aminotransferase is also found in red blood cells, red blood cells, while the concentration of enzyme in red blood cells can exceed the concentration of aspartate aminotransferase in plasma by 15 times, in case of any hemolytic pathologies that lead to the destruction of the structure of red blood cells( jaundice of newborns, anemia)a significant increase in the AST concentration.

Aspartate aminotransferase concentration in the child in the blood is observed in the following diseases:

• Ischemic disease, acute myocarditis;
• Necrosis of hepatocytes;
• Cholestatic or obstructive jaundice;
• Toxic hepatitis;
• Dermatomyositis, muscular dystrophy;
• Burns, severe injuries, bruises, thermal shock.

A slight increase in aspartate aminotransferase may be caused by medications or excessive physical exertion before testing.

Change in AST level during pregnancy

A slight increase in the concentration of AST in the blood during pregnancy is observed in such complications as fetal edema, moderate nephropathy. A significant increase in the concentration of the enzyme is noted in acute pancreatic diseases, heart diseases, violation of bile flow, pulmonary thrombosis, myocardial infarction.

The decrease in the level of aspartate aminotransferase concentration during this period, as a rule, indicates the insufficient intake of B vitamins( B1, B2, B5, B6) into the organism of the future mummy.

Aspartate aminotransferase level in the blood

As a rule, when diagnosing most pathologies and diseases, there is a sharp increase in the blood of this enzyme, but in some cases, namely, with vitamin B6 deficiency, azotemia, renal chronic dialysis, destructive liver lesions or organ ruptures- aspartate aminotransferase is lowered.

For any abnormalities in the level of aspartate aminotransferase in the blood serum, after giving all the necessary tests, doctors prescribe a comprehensive medication. Reduction of the level of enzymes of this group in the blood can occur independently, but only after complete elimination of the causes and treatment of the underlying diseases.

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