Symptoms and treatment of cortical atrophy, Alzheimer's disease

Cortical atrophy is the process of destructive changes that occurs in the cerebral cortex. It can be associated either with changes that occur in old age or pathological processes in the body. Most often, such a deviation is observed in the frontal lobes, which are responsible for thought processes, exercise control over human behavior, planning, but sometimes the process affects other parts of the cortex.

This condition is characterized by slow progression, occurs, as a rule, at the age of about 50 years, is more often manifested in women, and gradually leads to the development of senile dementia. Occasionally, cases of the appearance of such a pathology in newborns are recorded, this is due to burdened heredity.

The most well-known disease, accompanied by destructive disorders of the cerebral cortex, is bipolushary cortical atrophy, or Alzheimer's disease. It should be noted that only extensive process results in severe dementia, focal destruction usually does not have a significant effect on the patient's mental abilities.

Cortical atrophy is considered exclusively the disease that occurs as a result of changes in normal cells with a normal physiological function, if the central system does not develop during the intrauterine process of formation, then such a deviation is not considered atrophy.

Causes of the origin of the disease

Dysfunction and chronic ischemia occurring in the cerebral cortex may call for atrophic changes. This process occurs for a number of reasons, among which:

• Atherosclerotic changes in blood vessels with a decrease in their lumen and a decrease in blood flow.
• Disorders associated with the process of oxygen saturation of blood.
• Anemia. With it, hypoxic condition and regress of cellular structures occur.
• Change in regenerative abilities of cells.
• Acute and chronic infectious diseases of the brain.
• Ionizing radiation.
• Toxic effects of narcotic drugs, tobacco and alcohol.
• Traumatic injury associated with edema and malnutrition.
• Hydrocephalus.
• Constant low pressure.
• Vasoconstrictors.
• Slowly developing neoplasms that constrict the vessels of the brain.
• Initiation of the mechanism of hereditary predisposition to cellular degeneration. Neurosurgical operations.
• No mental stress.

Experienced specialists found that with initially high intellectual level, people who are engaged in mental work before their old age are less susceptible to the disease associated with atrophy of the cortical area of ​​the brain.

Any cause of cortical atrophy is only 5% of cases acquired. Most often they only act as a provoking or aggravating disease course against a background of genetically predisposed predisposition.

Clinical manifestations and diagnosis of

Symptoms of cortical atrophy depend on the extent and depth of damage to the cerebral cortex. With moderate changes, the following symptoms may appear:

1. The onset of the disease can be asymptomatic. In the first place there are complaints that are characteristic of another pathology. Sometimes there is weakness, dizziness, episodic headaches.
2. Further development of the pathological process leads to the fact that the person's ability to think analytically is reduced, memory processes are deteriorating. The patient ceases to evaluate himself critically, the speech is changing, the handwriting worsens. The behavior becomes conflict, the thread in the conversation is lost.
3. Progression of impairments leads to a change in motility and coordination. The patient constantly experiences unmotivated outbursts of anger, is characterized by defiant behavior. A far-gone form is expressed in the loss of basic skills of self-service.
4. At the final stage of the disease the patient becomes inadequate, disoriented. He ceases to understand the meaning of the surrounding events and does not react to them in any way.

Often, such a patient becomes dangerous to surrounding people, so he is placed in a psychiatric hospital.

To a variety of atrophic diseases of the brain tissues is Pik's disease, with this disease there is a pronounced thinning of the cortex. It is necessary to differentiate this ailment with Alzheimer's disease, since it can be curable at early stages of detection.

In Pick's disease, behavioral disorders involve increased distractibility and inability to concentrate. The patient can repeat the same phrase several times in conversation. It is also very characteristic of an increased attraction - there is gluttony, hypersexuality. This often happens against the backdrop of an inadequately gay mood and on the part of such a person appears morally dissolving. Progression of the disease is not too fast, but unswervingly.

The emergence of typical clinical signs of cortical atrophy requires additional studies. The diagnosis is confirmed after evaluating the results of CT or MRI.

How to treat cortical atrophy?

In the presence of pronounced age-related changes, treatment of a disease such as cortical cerebral atrophy is to take measures to prevent further progression. At a younger age, it is possible to achieve improvement in the state and a certain regression, provided that the cause can be eliminated.

Nootropics are used to improve the nutrition of brain cells. This - piracetam, cerebrolysin, nootropil. They help to ensure the improvement of thinking processes.

To increase the intensity of regeneration processes and prevent further progression of the disease, antioxidants are used.

Improvement of blood microcirculation and enhancement of metabolism is achieved by pentoxifylline or trental.

All other drugs are prescribed, based on the symptoms of the disease. With headaches, you can take non-steroidal anti-inflammatory drugs or analgesics, sleep disorders and increased nervous excitability requires the use of sedatives.

Moderate cortical atrophy does not require hospitalization of such a patient. To improve a person's condition, one should not change the habitual situation, this can speed up the progression of the disease and lead to death. Important moments in the treatment is the patient's peace of mind by taking sedatives, among them may be light antidepressants or tranquilizers.

It should be noted that daytime sleep and excessive free time with this type of disease is highly undesirable. It is better to surround the patient with attention and take household chores, to force him to be in motion as much as possible. Walking in the fresh air and moderate exercise are necessary.

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